IL-37 linked to gout pathogenesis and treatment

The Immunological Basis in the Pathogenesis of Gout

Hyperuricemia and gout: new insights into pathogenesis and treatment.

Over the past decade, significant advances have been made regarding the pathogenesis, clinical implications, and treatment of hyperuricemia. While physicians have understood for at least a century that uric acid causes gout, we are now beginning to address the question of why hyperuricemia exists and the mechanisms by which uric acid acts to stimulate inflammation. This review focuses on (1) pr...

Frozen shoulder: Pathogenesis, Diagnosis and Treatment

Frozen shoulder (FS) or adhesive capsulitis is a common disease which causes pain, difficulty and restriction in the movement of the shoulder joint due to unclear complex etiology. The everyday tasks such as bathing, dressing and driving become difficult. It affects both men and women especially in their 40s and 60s. The duration of the disease varies from one patient to another and it may last...

fluoride and dental fluorosis and treatment

چکیده ندارد.

IL-37 restrains autoimmune diseases

Interleukin-37 (IL-37), a newly discovered member of the IL-1 family, has been identified as a natural inhibitor of immune responses [1]. The human IL-37 gene has been confirmed undergo alternative splicing and exists in five splice variants including IL-37a-e, but a mouse homologue has not been reported [2]. The most glaring is IL-37b that encodes the longest transcript variant includes exons ...